Rare Earth Element‐Based Recovery Concept for Cofactors Containing Phosphate Groups from Aqueous Solutions

Cofactors, which are key components in many bio-based processes, often consumed within the biosynthetic reaction, but usually converted back to their original form by recycling. This study presents an approach for selective removal of cofactors from aqueous solution at up submillimolar concentrations. The rare earth elements (REE) scandium, yttrium, and lanthanum, oxidation state +3, used sparingly soluble salts with investigated cofactors, pyridoxal-5-phosphate, NAD+, NADP+, adenosine triphosphate, thiamine pyrophosphate. Up > 99 % efficiency via cofactor salt precipitation was observed. Redissolution recovery formed is obtained treatment NaH2PO4 a metathesis forming solubilized corresponding REE phosphate salts.